Informatics Publishing Limited

Bandagisa Fouziya ¹, Hindustan Abdul Ahad ², Dontha Swamy Charan ¹, Jagarlamudi Sri Vidya ¹, Ummadi Chandana Reddy ¹, Puli Nandini Reddy ¹

Affiliations
1 Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, IN
2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu, Andhra Pradesh, IN

Abstract

The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.

Keywords

Niosomes, Spans, Cefpodoxime Proxetil, Cholesterol, Injection, Evaluation

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Lami Singh ¹, Hindustan Abdul Ahad ¹, Bandaru Pavan Kumar ¹, Vadde Madhusudhan ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu - 505721, Andhra Pradesh,, IN

Abstract

The present work aims to raise awareness of the new Corona Virus (CoV) variant, Delta Virus AY.4.2, among the general population. Scientists have found a mutation in the Corona Virus variant known as the Delta Virus. This literature review has been conducted in which the study proposes that it has given rise to the new strain of the CoV, AY.4.2, which has evolved from a super-spreading variant, called the Delta Virus, that binds and invades the body’s cells of the patient. The variant, or the sub-strain, has been detected in at least 24 countries now, according to World Health Organization Epidemiological statistics, including countries like the United States, India, the United Kingdom, Israel, and Russia. The Delta plus variant, which is the new mutant variant, has much better competitive survival chances than the other variants. According to scientists and researchers, AY.4.2, this CoV variant, has a faster onset of spread and infection. This variant has similar signs and symptoms to those of the Delta Virus and the CoV. If any symptoms happen to appear in any person, they are advised to consult a doctor, get themselves tested for COVID-19, and isolate themselves until they are recovered. Researchers conclude that after determining the fatality and potential severity of the variant, it is recommended that the public maintain social distance in crowded places while also taking precautionary measures to avoid meeting the virus. If any symptoms happen to appear in any person, they are advised to consult a doctor, get themselves tested for COVID-19, and isolate themselves until they are recovered.

Keywords

Corona, Delta, Differences, Lineage, Variant, Lineage.

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Lakunde Sathish Kumar Jyothika ¹, Hindustan Abdul Ahad ¹, Chinthaginjala Haranath ¹, Shaik Kousar ¹, Hothur Dharani pal Gowd ¹, Sampathikota Halima Sadiya ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, IN

Abstract

The work is aimed at giving an overview of transdermal drug delivery systems (TDDS). In TDDS, an effective amount of a drug is applied across the skin at a controlled rate for the systemic effect. TDDS has become increasingly popular. In the last 30 years, it has been proposed as a potential new drug delivery system. These comprise more efficacious treatments and a reduced risk of adverse events; ensure safety; maintain steady-state plasma levels of drugs, while incapacitating the significant hitches of conventional oral dosage forms and parenteral preparations. It is best suited for diseases that require long-term, frequent dosing treatment. This review deals with drugs, polymers, and methods adopted in making TDDS in recent years by referring to reputed journals and textbooks. The authors succeed in gathering the information and the literature on the TDDS. The study concludes that the literature so far will help the researchers with a quick reference on the attempts so far made on TDDS.

Keywords

Drug, patches, stratum corneum, polymer, transdermal.

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Yarragunta Roja ¹, Hindustan Abdul Ahad ¹, Haranath Chinthaginjala ¹, Maninjeri Soumya ¹, Sana Muskan ¹, Nagaraju gari Kavyasree ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, IN

Abstract

The present article concentrates on the Buccal film. It is a buccoadhesive drug delivery system that enhances the safety, efficacy, and stability of active pharmaceutical ingredients. The buccal film is a novel technology due to its better option to optimize therapeutic efficacy. This drug delivery system is suitable for drugs that pass through high first-pass metabolism and are used for enhancing bioavailability. The buccal film can be formulated as a solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, or rolling method. Among them, the solvent casting method is mostly adopted. The buccal films are evaluated for mechanical properties viz., Organoleptic assessment, thickness, dryness, tack test, tensile strength, percent elongation, folding endurance, swelling assets, surface pH, contact angle, transparency, uniformity in drug content, disintegration, and in-vitro dissolution tests. The article gave a handful of literature on past work done on buccal films. This article helps with quick references to the earlier attempts so far made on buccal films.

Keywords

Buccal, Bioavailability, Film, Literature, Patient convenience.

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Hindustan Abdul Ahad ¹, Haranath Chinthaginjala ¹, Nagarajugari Kavyasree ¹, Jyothi Vinay Krishna ¹, Sushma Papireddypalli ¹, Kotlo Saijyoshna ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, IN

Abstract

The purpose of this study was to investigate previous research on fast-acting pills. Fast dissolving tablets (FDTs) have become a rapidly emerging field in the pharmaceutical business over the last ten years. For the administration of many medications, oral drug delivery remains the recommended method. Scientists have developed FDTs with increased patient compliance and convenience during insertion into the mouth because of recent technological advances. For simple administration of active pharmaceutical substances, these tablets crumble or dissolve in the mouth without the use of water. Because of the formulation's popularity and use, several FDT technologies have been developed. FDTs are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without the use of water or chewing. FDT shines in areas where pediatrics and geriatricshave trouble swallowing traditional tablets and capsules. FDT is a new drug delivery system that is intended for rapid dissolution and action, as well as treating acute illnesses with greater patient compliance. The authors gathered enough data from previous FDT trials. This review article can be used by researchers to quickly obtain latest literature on FDT.

Keywords

Disintegrating, Literature, Mouth dissolving, Past work, Polymers.

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Shaik Kousar ¹, Hindustan Abdul Ahad ¹, Haranath Chinthaginjala ¹, Peddagundam Babafakruddin ¹, Jyothika Lakunde ¹, Ksheerasagare Tarun ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu-515721, Ananthapuramu, Andhra Pradesh, India., IN

Abstract

The main objective of the present study is to give a general view of gas-generating floating tablets and past work done on them. The authors gave an overview of gas-generating floating tablets by referring to peer-reviewed journals, magazines, and books. The data so obtained was encrypted and compiled. The outcome of this data is the generation of a literature that helps the researchers quickly refer to the pasty work done on the gastroretentive floating tablets. The study concludes that the gas generating floating tablets not only increase gastric residence time but also provide a prolonged therapeutic effect .

Keywords

Controlled drug release, Drug delivery, Effervescent system, Floating system, Gastric retention.

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